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The reduction in BW from baseline was 22% at the maximum dose tested (mean SEM, 100 nmol/kg from 43.6 1.6 g to 34.8 1.4 g) and 10% from baseline at the lowest dose tested (mean SEM, 1 nmol/kg, from 42.5 1.3 g to 38.2 1.3 g) (Figure 1, A and B)
The studys limitationsmall sample sizes without large-scale RCT confirmationmatters for clinical translation but doesnt negate the mechanistic evidence
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Beyond Potency: The Safety Hazards of Visible Abnormalities The presence of visible particles is particularly concerning because this may: Represent peptide aggregation Microbial contamination Interaction between the drug and container components Even small particles that settle at the bottom of the vial warrant discarding the medication
Semaglutide and liraglutide belong to a family of GLP-1 (glucagon-like peptide-1) receptor agonists
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