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A 5 to 10% weight loss can lead to MASH resolution in humans [4] and in rodents [16]

Adjusting meal size and frequency helps, for example splitting intake into four to five smaller plates per day reduces stomach backlog and lowers the chance of reflux when digestion is slowed

But for most people reading this, tirzepatide is the only practical option today and the evidence for starting now rather than waiting is stronger than the 6-percentage-point efficacy difference might suggest

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TRIUMPH-1's prespecified 104-week extension (BMI 35 subgroup) showed average weight loss reaching 30.3% higher than the 28.3% at week 80