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A double stranded small-interfering RNA (siRNA) to the ANGPTL3 mRNA, that is conjugated to GalNAc (identified as ARO-ANG3), has shown promise at hepatocyte-specific reduction in ANGPTL3 mRNA levels
Non-diabetic patients who received 15mg weekly for 72 weeks (about 17 months) lost an average of 22.5% of their body weight, compared to 2.4% of the placebo group
An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimers disease-associated A oligomers
2022;34:e13132
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