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Erysipelatoclostridium relative abundance was significantly greater in the vehicle-treated group switched from WD to LD relative to all other groups (before FDR correction, Fig

However, more participants discontinued treatment with tirzepatide 10 mg (OR 2.39 [95% CI 1.02, 5.59], I 2 0%) and 15 mg (OR 3.64 [95% CI 1.51, 8.78], I 2 13%) when compared with placebo (ESM Table 3)

DSIPs effects on the CRF pathway and cortisol regulation make it particularly relevant for stress-induced sleep problems

The results firmly established the superiority of the dual-agonist approach

It is specifically prescribed for adults with a body mass index (BMI) of 30 or higher, or 27 or higher if they have a related health condition like type 2 diabetes, high blood pressure, or high cholesterol