glp-1 kidney protection receptor agonists are increasingly used to treat type 2 diabetes and #obesity, and trials have shown reductions in cardiovascular risk and slowing of failure. Adverse events are mostly gastrointestinal. Read Renal effects of GLP-1 receptor

AbbVies tavapadon targets motor symptoms of Parkinsons with a more specific mechanism than existing drugs, potentially meaning more benefits with fewer side effects

Whiting PH, Kalansooriya A, Holbrook I, Haddad F, Jennings PE

GLP-1 is rapidly degraded by an enzyme named dipeptidyl peptidase-IV (DPP-4), converting to bioinactive products GLP-1 (9-36) and GLP-1 (9-37) ( GLP-1 exerts its function by binding to GLP-1R and is involved in the development and progression of many diseases ( GLP-1R agonists (GLP-1RAs) are a group of GLP-1 analogues that are resistant to DPP4-mediated degradation, working through activating GLP-1R and its downstream signaling ( The expression of GLP-1R remains controversial due to the lack of specific antibody against GLP-1R, with most of the literatures using qPCR to detect mRNA levels ( 2 GLP-1 in regulating immune system 2.1 The role of GLP-1 in innate immune cells Recent studies have demonstrated that GLP-1 and its analogues exert regulatory functions in innate immune cells, especially macrophages

Cefaclor causes vagus nerve-mediated depression-like symptoms with gut dysbiosis in mice

M.MiskellyM