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This leads to multiple metabolic effects, as well as decreasing inflammation and neuroprotective effects.[ref] Two GLP-1 receptor agonists (RAs) currently approved for weight loss are liraglutide and semaglutide
GHS-R1a activation stimulates GH release through a different intracellular pathway (phospholipase C, IP3/DAG) and also activates GHS-R1a expressed on corticotrophs and lactotrophs, explaining co-secretion of ACTH/cortisol and prolactin
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