how does tirzepatide help pcos Possible protective effects of on polycystic ovary syndrome in female rat model induced by testosterone propionate in comparison to metformin | Naunyn-Schmiedeberg's Archives of Pharmacology Tirzepatide for PCOS: Insulin Resistance

Enhancements in immune function markers were also observed

Current evidence from large-scale clinical trials and regulatory surveillance does not establish a causal link between GLP-1 receptor agonists and increased risk of venous thromboembolism (deep vein thrombosis or pulmonary embolism)

Physical activity A 2026 Cochrane review of 73 randomised controlled trials involving nearly 5,000 adults found that exercise produces a moderate reduction in depressive symptoms, with effects comparable to psychological therapy

The STEP 1 trial showed average weight loss of 14.9% over 68 weeks, with around half of participants losing 15% or more of their body weight

If you believe your medication is affecting your weight, discuss alternatives with your GP or specialist, as many conditions have treatment options with more favourable metabolic profiles