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Hydroxychloroquine can inhibit iNOS levels in macrophages (109), downregulate M1 markers, and upregulate certain M2 markers, thereby promoting the transition of macrophages from the M1 to the M2 phenotype (110, 111)

Quick Comparison Feature CagriSema Retatrutide Development owner Novo Nordisk Eli Lilly Core strategy Combination therapy Single-molecule multi-agonist Pathways Amylin + GLP-1 GIP + GLP-1 + glucagon Main components Cagrilintide + semaglutide Retatrutide (LY3437943) 2026 status Phase 3 / regulatory-watch candidate Phase 3 TRIUMPH program Best-fit research question Can amylin extend GLP-1 results

The transition periods were specific

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Peto R, Davies C, Godwin J, Gray R, Pan HC, Clarke M, et al