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An early study by Jackson and Halestrap (130) documented lactate-induced intracellular acidification in rat hepatocytes, whereas Bozzo et al (131) observed only modest pH reductions following 5 mM lactate treatment in mouse neurons
BMI of 25 or higher
Despite extensive investment in MASH drug development, only one medication (resmetirom) has been officially approved for MASH treatment to date
And in the vast majority of cases, it resolves on its own within 24 to 48 hours without any intervention at all
The mechanism: cortisol primes adipocytes for lipolysis by upregulating -AR density and downregulating alpha-2 adrenergic receptors (which inhibit fat release)
