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The Journal of Physiology
The increase in glucose-6-phosphate that results from inhibition of PFK1 leads to feed-back inhibition of hexokinase which in turn limits glucose uptake via GLUT4
Compounds Trevogrumab (also known as REGN1033 or -MSTN) and garetosmab (REGN2477, -ActA) are fully human recombinant immunoglobulin (Ig) G4 monoclonal antibodies which specifically bind and inhibit myostatin and ActA (as well as INHBA-containing heterodimers, including activins AB and AC), respectively
The genetic test reveals predispositions in peptide pathway signaling that may correlate with responder phenotypes described in clinical literature
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