Moreover, Ex-4 induces autophagy and attenuates ovarian cancer cell viability by upregulating the expression of autophagic markers beclin-1 and microtubule-associated proteins light chain 3I/II (LC3I/II), while simultaneously downregulating the expression of p62 (a linker protein for LC3II) [68]
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The findings revealed that all three ILs played a significant role in promoting hypercoagulability in whole blood and that IL-8 had a notable effect on erythrocyte structure, leading to visible changes in the cell membrane and the initiation of eryptosis
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The peptide's ability to increase superoxide dismutase activity is particularly significant, as SOD catalyzes the dismutation of superoxide radicals into less harmful molecules, providing a first line of defense against oxidative stress