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In some cases, improved insulin sensitivity may actually support metabolic health

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Safety Considerations and Who Should Use B12-Enhanced Formulations B12 supplementation is generally well-tolerated

Conversely, nutritional therapy involving the administration of beneficial bacteria such as Bifidobacteria, Lactobacillus , and probiotics can attenuate HPA axis activity, restore normal ACTH, CORT, and BDNF levels, and exert an antidepressant effect (Sun et al., 2022)

[Accessed Nov 2023] Bethel MA, Diaz R, Castellana N, Bhattacharya I, Gerstein HC, Lakshmanan MC