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Mowrer has a few suggestions for minimizing GI symptoms related to these drugs: Hydrate
They do not replace them
A 2026 biopharmaceutical review in a journal I do not trust said there is no identified high-affinity receptor, no validated molecular target, and a wide disconnect between the tidy preclinical effects and any coherent pharmacology
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It activates G-protein coupled receptors FFAR2 and FFAR3 on L cells, triggering calcium influx and subsequent GLP-1 vesicle release
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