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Striking accumulations and excess excretion of heme pathway intermediates and their oxidized products give a characteristic red (or dark) urine color
For example, people with certain heart conditions need to be cautious because Zofran has been linked to a risk of heart rhythm problems in some cases
Inclusion/Exclusion Criteria and Adverse Events were listed in Table S1a
Despite the short plasma half-life, downstream biological effects in tissue persist substantially longer, consistent with a signaling cascade rather than direct dose-response activity
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