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In contrast, 25.45% (14/55) of the H 2 O 2 -treated zygotes exhibited features of aberrant microtubule formation, including loss of spindle bipolarity, microtubule breakage, monopolar spindles, and elongated spindles accompanied by chromosome misalignment at metaphase, which may act as a trigger for micronuclei formation (vs

New England Journal of Medicine , 387(3), 205-216

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