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This binding activates adenylate cyclase, producing cyclic AMP (cAMP), which stimulates protein kinase A (PKA) and ultimately enhances growth hormone (GH) gene expression and pulsatile GH secretion
Although the number of beige adipocytes did not increase, they displayed a more thermogenic phenotype characterized by smaller LDs, elevated expression of uncoupling protein 1 ( UCP1 ) and HSL , and enhanced glucose utilization, all features consistent with increased mitochondrial uncoupling and browning
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