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10.1016/j.jsbmb.2017.01.021 142 PonziniE.ScottiL.GrandoriR.TavazziS.ZambonA
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Impairment of these redox currency systems compromises both antioxidant defense and mitochondrial bioenergetic stability [83]
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Mechanistically, high TFRC expression negatively correlates with the infiltration levels of key anti-tumor immune cells such as CD8 + T cells and positively correlates with immunosuppressive cells like Th2 cells, suggesting it promotes disease progression and poor prognosis by modulating the tumor immune microenvironment ( STEAP3 is a metalloreductase and a crucial regulator of ferroptosis
