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Description

Tumorbearing mice were injected with fully labeled [U 13 C]glutamine and mass spectrometrybased isotopic tracing of liver tumors was performed and compared to adjacent nontumor liver tissue (Fig EV3B and C)

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Decades ago, Otto Warburg put forward that cancer cells depended on glycolysis to support cellular growth even under normoxic conditions (the so-called Warburg effect) (35, 36)

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