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Here we report its design, preclinical development and clinical proof-of-concept study to evaluate the safety, tolerability, PK and pharmacodynamics (PD) of AMG 133

The 2.4 mg group lost the most weight, which means that among adults suffering from overweight or obesity and T2DM, SMG 2.4 mg once a week has achieved significant clinically significant weight loss ( 2 (or 27 kg/m 2 with more than 1 body weight-related coexisting disease)

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