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While it is not known if the impact on blood pressure was due to the medication or the participants weight loss, the lower blood pressure measures seen with tirzepatide rivaled what is seen for many hypertension medications. The current research was a planned sub-study including 600 of the participants from the SURMOUNT-1 weight loss study to determine if there was an effect on blood pressure
Lower TCA cycle intermediates (citrate, a-ketoglutarate) with AmAc did not occur with Hif1 KO
GLP-1 receptor agonists as a pharmacological class are well-studied
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