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The GSSG-dependent oxidation of roGFP2 by fused PfGrx variants is two to three orders of magnitude faster than the oxidation by unfused PfGrx(SSG) variants and more than seven orders of magnitude faster than the uncatalyzed reaction with GSSG (Table 1)

Moreover, it has been previously shown that GPX4 overexpression in cancer cells inhibits RSL3-mediated ferroptosis, whereas GPX4 deletion increases susceptibility to ferroptosis [22]

As a major bonus, the phospholipid complex provides natural flavor masking , reducing the sulfur taste associated with standard glutathione supplements

Nature (2009) 461:78892

doi: 10.2147/VHRM.S205996 97 HikinoH.KonnoC.MirinY.HayashiT