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This is known as the bioavailability gap
Start slowly if you are new to active skincare If you are introducing a new cream into your routine, begin with once-daily use and observe how your skin responds over a few days
no KLOW trial Community approach Extended cycle Reported duration 8-12 weeks Reported break About 4 weeks Evidence level Reported in community protocols
C.GermeyerA.et al (1998)
Ethics statement The studies involving humans were approved by Ethics Committee of Second Affiliated Hospital, Zhejiang University School of Medicine
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