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While oral semaglutide produces meaningful weight loss, injectable formulations consistently outperform, and more patients discontinue oral semaglutide due to gastrointestinal side effects
This is likely due to the more established CKD-specific evidence base available for SGLT2is [10,11,12], and the fact that FLOW evaluated semaglutide in patients receiving prior guideline-directed standard of care, limiting generalisability to GLP-1 RAs more broadly as a first-line therapy [8, 9]
The dosing can be customized allowing more nuanced micro-dosing
Soon JW, Manca MA, Laskowska A, Starkova J, Rohlenova K, Rohlena J
Quick Answer: GLP-1 injections can cause tiredness, classified as a common side effect affecting between 1 in 10 and 1 in 100 people, particularly at higher doses used for weight management
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