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In published phase-2 literature, retatrutide has been studied for its effects on body weight and metabolic markers, with the triple-receptor mechanism investigated as a way to pair appetite signalling with increased energy expenditure

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Dulaglutide is an effective medication for diabetes management and reducing the risk of blood vessel-related and heart diseases

Side effects are manageable and well-characterized

Because food reaches the intestines at different rates, the intestines may temporarily respond with increased fluid retention or faster propulsion, both of which can contribute to diarrhoea