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We adjust by indication and severity, not body mass

Rationale for DPP-4: A New Class of Oral Agents for the Treatment of Type 2 Diabetes Mellitus

Patients should be advised to: Eat smaller, more frequent meals rather than large portions Avoid high-fat, greasy, or heavily spiced foods that delay gastric emptying further Stay well hydrated with small, frequent sips of water throughout the day Avoid lying down immediately after eating

The underlying mechanisms for increased HR remain to be fully elucidated, but may be related to a direct GLP-1 receptor effect on myocytes in the sinoatrial node of the human heart and/or stimulation of the sympathetic nervous system

Slows gastric emptying