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After stopping GLP-1s, hunger-promoting hormones can increase while energy expenditure may dip slightly, a pairing that can promote weight gain

These can include changes to the nervous system and feedback mechanisms involved in appetite signaling, which could reduce caloric intake and result in fatigue

We don't necessarily know exactly why it seems to be impacting people with PCOS a little bit more than the general communityand there's a lot of research that needs to be donebut I think there's a lot of people in the PCOS community that are really excited about the potential of this medication to be a game changer, she says

Understanding these variables can help you and your clinician make informed decisions about continuing, adjusting, or potentially stopping treatment

(Journal of Investigative Dermatology, 2012) published landmark GHK-Cu research using microarray technology to map genome-wide expression changes