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The broader record: case reports document melanoma developing in Melanotan II users, and rapid changes in moles and pigmented lesions that make detecting skin cancer more difficult

Individuals with type 1 diabetes, thyroid cancer, multiple endocrine neoplasia, or end stage kidney disease at any time until cohort entry or individuals with dialysis or the latest eGFR 70 years, by males versus females, by insulin use, by atherosclerotic cardiovascular disease (i.e., myocardial infraction, angina, coronary artery disease, coronary revascularization, peripheral artery disease, aortic atherosclerotic disease, or cerebrovascular disease), by renal insufficiency (i.e., chronic kidney disease or the latest eGFR 70 years (HR [95% CI]: 0.95 [0.831.08])

Microdosing semaglutide refers to taking the medication in low doses or administering standard doses at longer intervals than the FDA-recommended dosing guidelines, to get potential benefits with fewer side effects

H2-receptor antagonists (e.g., famotidine) are another option for acid suppression

Gde et al., 2003