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These drugs work by amplifying natural gut hormones that coordinate metabolism across multiple organ systems - the breakthrough came from Gila monster venom, which led to engineered peptides that last days instead of seconds

A drug that would previously have maintained high net pricing through its remaining exclusivity period now faces a Medicare-set negotiated price that may significantly reduce the revenue available in those final exclusivity years

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No overall differences in safety or effectiveness were observed between subjects 65 years and over and younger subjects

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