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Consequently, individuals with normal or near-normal BMI are now seeking semaglutide to shed a few kilos without any underlying medical indication
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Individual response varies significantly, and both are normal
The peptide carries 2-aminoisobutyric acid substitutions at positions 2 and 20 to resist dipeptidyl peptidase-4 degradation, a C-terminal amide, an N6-substituted lysine C18-diacid fatty acyl side chain for albumin binding and half-life extension, and a 2-methyl leucine substitution for selectivity tuning
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