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Here, we demonstrate that dihexa binds with high affinity to hepatocyte growth factor (HGF) and both dihexa and its parent compound Norleucine 1-AngIV (Nle1- AngIV) induce c-Met phosphorylation in the presence of subthreshold concentrations of HGF and augment HGF- dependent cell scattering

Multiple clinical trials have established dosing ranges and administration protocols that optimize metabolic benefits while maintaining excellent safety profiles

\Sustained Efficacy: Long-term weight and glycemic control maintained for up to 2 years

They do not undergo FDA premarket review for safety, effectiveness, and quality