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Naltrexone is more targetedit blocks a specific piece of the alcohol reward pathway

GLP-1 agonists bind to GLP-1 receptors on pancreatic beta cells, stimulating insulin secretion in a glucose-dependent mannermeaning they only promote insulin release when blood glucose levels are elevated

As primarily secreted proteins, IGFBPs are released into the extracellular space, where they interact with IGF-1 (Oxvig and Conover, 2023)

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Each peptide has its own evidence base, but the combination has not been extensively studied in Phase III randomized controlled trials, and the article characterizes what exists as primarily case reports and observational context