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This entire process is highly dependent on cellular energy, requiring adenosine triphosphate (ATP) to function correctly

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19,20 Subchondral bone sclerosis, 21 meniscal tear and extrusion, 22 and synovial membrane inflammation (synovitis) 23 may also occur due to the mechanical changes in OA cartilage, and make OA disease more debilitating (Figure 1)

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The study used 120 minutes of moderate-intensity exercise per week