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Shingina A, Mukhtar N, Wakim-Fleming J, Alqahtani S, Wong RJ, Limketkai BN, Larson AM, Grant L

Medication: Both the pill and injection forms of Wegovy and Zepbound will be covered

In the kidney, betaine helps stabilize cellular proteins from urea and it acts as a methyl group donor in the liver

Injectable weight loss medications like semaglutide (sold under the brand names Ozempic and Wegovy) and tirzepatide (Mounjaro and Zepbound) can be very effective at treating obesity

At the same time, trial designs are evolving to account for lean-mass considerations, maintenance dosing strategies, amylin analogs, and the growing documentation burden tied to prior GLP-1 exposure