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In contrast, Zepbound has already demonstrated strong efficacy and safety across multiple Phase III programs, driving its rapid uptake in both diabetes and obesity
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In participants with type 2 diabetes, retatrutide lowered HbA1c by up to 2.02.2% at 3640 weeks across doses, with improvements in fasting glucose, insulin sensitivity, and a high rate of reversion from prediabetes to normoglycemia (up to 72% in relevant cohorts)
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The researchers also looked at studies that analyzed how GLP-1 drugs affected substance abuse disorders, psychotic disorders, and mood and anxiety disorders
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