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Several factors can impact the rate and total amount of weight loss on tirzepatide, says Fernando Ovalle, Jr., MD, ABOM , a double board-certified plastic surgeon and obesity medicine specialist

Suicidal behavior Using semaglutide for weight loss can cause changes in mood and behavior, including worsening depression and suicidal thoughts and behavior

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Receptor sensitivity

Contact your GP if you have dark brown urine persisting despite increased fluids, urine changes with severe vomiting or abdominal pain, signs of dehydration (dizziness, dry mouth, reduced urination), or red/cloudy urine suggesting infection or bleeding