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The pressure differential is why bubbles form in the syringe: you're pulling solution through a pressurized system that's simultaneously pushing back
This inability to induce hypoglycemia, or low blood sugar levels, in IV-administered GLP-1 led to the development of GLP-1 receptor agonists
For a broader overview of the full semaglutide class including Wegovy and the cardiovascular outcomes evidence in obesity, see our dedicated article: Semaglutide and Cardiovascular Prevention, What the Major Trials Show
doi:10.7759/cureus.32803
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