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91 Although autophagosomes are often increased in MASLD, reductions in BECN1 and accumulation of p62/SQSTM1 indicate defective lysosomal degradation and impaired autophagic flux.1, 92 This dysfunction affects lipophagy, insulin signaling, inflammatory responses, and cellular stress pathways

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10.1177/11795549241283421 Clin Med Insights Oncol