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The signs of skin aging in women can vary with the passage of time
Metformin inhibits the production of reactive oxygen species from nadh:ubiquinone oxidoreductase to limit induction of interleukin-1beta (IL-1beta) and boosts Interleukin-10 (IL-10) in lipopolysaccharide (LPS)-activated macrophages
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10.1016/j.abb.2012.04.014 Vido K, Diemer H, Van Dorsselaer A, Leize E, Juillard V, Gruss A, Gaudu P: Roles of thioredoxin reductase during the aerobic life of Lactococcus lactis
While this does not guarantee visible anti-aging effects, it explains why it is frequently discussed in longevity-focused protocols
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