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Treatment must be initiated and supervised within specialist weight management services (Tier 3) and is typically time-limited
Unlike older therapies, tirzepatide simultaneously engages both GLP-1 and GIP pathways, leading to reduced hunger, prolonged satisfaction, improved insulin response, and potential increased calorie burn
Patients should start with the gentlest effective optiontypically PEG 3350and escalate only if necessary, always under healthcare provider guidance
2 Various oral and injectable therapies are available with the goal to improve glycemic control
Dr Spreckley, who is leading AMPLIFY, said: These medications are transforming obesity care, but we know very little about how they shape peoples daily lives, including changes in appetite, eating patterns, wellbeing, and quality of life
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