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Unlike traditional bicarb which peaks unpredictably, the controlled intestinal release makes that timing window more reliable.
That leads to five serious challenges for self-funded employers: High discontinuation rates
References Kojima M, Kangawa K
This is seen when the plasmatic levels are above 5060 pM, equivalent to more than five times the levels seen post-prandial in healthy individuals challenged with a bolus of glucose, or 10-fold their basal levels (153, 216), adding further doubt to the physiological hormonal dogma of intestinal GLP-1
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