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The difference isnt dramatic, but rates of nausea and diarrhea are modestly higher with tirzepatide compared to semaglutide in clinical trials

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Some people experience side effects like restlessness, dry mouth, increased heart rate, or difficulty sleeping

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Emerging research has identified GLP-1 receptor expression in kidney tissue and the urinary tract, suggesting that semaglutide may have direct effects on urinary tract biology that we are only beginning to understand

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Duxford: Woodhead Publishing

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Originally developed for diabetes treatment, these peptide-based drugs are now widely used for metabolic disorders and weight management

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