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Its inactivation reduces metastatic potential but increases cancer cell proliferation compared to the heterozygous deletion of Smad4 alone [298]

Clinical approach recommendations include starting with the most conservative effective therapy, optimizing tirzepatide dosing before adding other agents, regular monitoring of cardiovascular parameters and metabolic markers, and setting realistic weight loss goals (5-10% initial target)

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Eligible beneficiaries will only pay a $50 copayment for each 30-day supply of their weight loss medication