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However, when it mutates, IDH converts -KG to 2-hydroxyglutaric acid (2-HG) and competitively inhibits -KG-dependent DNA and histone demethylases (Xu et al., 2011), leading to a hypermethylation phenotype and may alter the differentiation of cancer stem cells (Yang et al., 2012
The role of epigenetics in the pathology of diabetic complications
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Other warnings Intensive therapy for megaloblastic anemia may result in hypokalemia, thrombocytosis, and life-threatening complications
Peer-reviewed studies relevant to Dihexa are listed in the Citations tab on this product page
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