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When a cell over-expresses NNMT, it does two costly things at once: it burns through methyl-donor capacity, and it diverts nicotinamide away from NAD+ regeneration into an inert metabolite (1-methylnicotinamide) that gets excreted

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The Pyo 2007 study used AHK-Cu at picomolar to nanomolar concentrations for DPC proliferation effects remarkably low concentrations that suggest high biological potency

Patients with a history of allergy to vitamin B or cobalt should not receive this injection