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Full-length human growth hormone represents the central mediator of this axis and is commonly used in research to examine direct growth hormone receptor activation and downstream signaling networks such as JAK2/STAT pathways
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Special monitoring may be needed for diabetes medications (though AOD-9604 doesnt affect glucose metabolism), cardiovascular drugs, thyroid medications, or other growth hormone-related therapies
Importantly, 5MQ was found to effectively inhibit HeLa cell proliferation without apparently affecting normal HEK-293 cell proliferation suggesting selectivity for cancer cell biology contexts
That was the idea devised by Australian biochemist Frank Ng his colleagues of Monash University in the 90s
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