tirzepatide onset of action Tirzepatide, a New Era Dual-Targeted Treatment for Diabetes and Obesity: A Mini-Review Pharmacogenomics of Tirzepatide: Genomic Insights

This allows them to pass intact to the small intestine, where absorption occurs

Hug G, McGraw CA, Bates SR, Landrigan EA

The objective of this study was to compare the efficacy and safety of tirzepatide with titrated insulin degludec in individuals with type 2 diabetes who had inadequate glycemic control despite treatment with metformin alone or in combination with SGLT2 inhibitors.In this phase 3 study, participants aged 18 years or older, with a baseline glycated hemoglobin (HbA1c) of 7.0-10.5%, body mass index of at least 25 kg/m2, stable weight, and no prior insulin treatment, were enrolled across multiple centers in 13 countries

All-cause and cardiovascular mortality in middle-aged people with type 2 diabetes compared with people without diabetes in a large U.K

Its not that you cant use them at all, just not in the same application