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Landmark preclinical studies using animal knockouts have demonstrated that GLP-1 receptors in the brain are capable of controlling food intake and body weight, in addition to the hypophagic effects of endogenous GLP1 via peripheral GLP1 receptors [33]
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These clear effects (observed through comparison with various comparators, including current weekly GLP1-RAs on the market) are complemented by interesting data on cardiovascular safety and efficacy (from post-hoc studies) regarding the incidence and progression of nephropathy and hepatic steatosis
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