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Free radicals and oxidative stress not only damage proteins but also attack DNA, leading to gene mutations and even cancer
We demonstrated that the TSS pathway is ineffective in supraphysiological cystine concentrations but is critical under physiological cystine supplementation or excess hemin exposure in SCD erythroblasts
One study has shown that a factor V level less than 10% of normal indicated a poor prognosis (91% mortality), whereas a ratio of factor VIII to factor V of less than 30 indicated a good prognosis (100% survival)
The specific mechanisms remain under investigation, but the finding adds another dimension to DSIP's systemic regulatory effects
Patients who are interested in taking antioxidants during therapy should consult with their oncologist
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