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suggest direct activation of IGN genes in enterocytes by butyrate, while proprionate stimulates Gpr-41 in the periportal afferent neural system and indirectly activates IGN via a gut-brain communication axis [121]

The same trials are also the only window onto long-term safety: what are the implications of the elevated resting heart-rate in patients with heart failure or irregular heartbeats, let alone healthy individuals considering the longer term health implications of these drugs

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