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In a Phase IIb randomized, placebo-controlled trial involving about 160 patients, those who received monthly injections of ION224 for nearly a year showed marked improvements in liver fat, inflammation, and fibrosis, and remarkably, these benefits occurred even without weight loss
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AmatoABaldassanoSLiottaRSerioRMulF
A compound working topically, orally and systemically in one model either has unusually good distribution properties, or produces its effect through a mechanism less dependent on local concentration than would normally be assumed
First-in-elephant, proof-of-concept vaccination study Study design Study elephants Equivalent to phase I vaccine trial standards, healthy adult elephants rather than EEHV-susceptible calves were chosen for this first-in-elephant proof-of-concept study
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